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Chemotherapy was potentiated by E7449 and single agent had considerable antitumor activity in BRCA-deficient xenografts. On top of that, E7449 inhibited Wnt/β-catenin signaling in colon most cancers mobile strains, probable through TNKS inhibition. In step with this risk, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and noticeably altered https://lillians741kps5.ja-blog.com/profile

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