This methylation profile is already acquired at the MBL stage3 and continues to be comparatively steady after a while. Having said that, some CLL have intratumor variability in selected locations, which can change the expression of several genes and facilitate tumor evolution.71 Of note, this variability is larger in U-CLL https://dallasncrgv.sharebyblog.com/32349276/the-best-side-of-situs-judi-mbl77