Limb-threatening or vital limb ischemia (CLI) is manifested by Persistent (in excess of two weeks) ischemic relaxation agony, ischemic wounds or tissue reduction, or gangrene in one or both legs. Ischemic rest agony normally happens soon following falling asleep; the patient is awakened by burning agony or numbness inside the https://www.sgvascularctr.com/treatment-of-peripheral-artery-disease-pad-in-singapore-a-comprehensive-guide/