Elevated homocysteine concentrations have been associated with methotrexate-induced neurotoxicity. Based on methotrexate and homocysteine plasma concentrations of 494 children with acute lymphoblastic leukemia treated with high-dose methotrexate in the TOTAL XV study. a pharmacokinetic/pharmacodynamic (PK/PD) model was built with NONMEM. Several compartment and indirect response model... https://www.markbroyard.com/best-catch-acure-ultra-hydrating-plant-ceramide-daily-facial-lotion-50ml-fashion-great-buy/